The assignment should consist of one review article on the latest Literature

The assignment should consist of one article on the latest developments on the pathophysiology of a named disease. (Drug treatments for Alzherimers Disease) - Literature review Example Developing management plans for the disease has been a daunting task that is still being researched on. It has been established that the disease cannot be cured but it can be managed to prevent continued degeneration. Anticholinergic drugs were used at that time with the use levodopa being adopted later. This was done after the discovery of dopaminergic deficits in the pathophysiology of the disease. The disease is quite common and affects the nervous system with patients having symptoms such as tremor, slowness in movement, rigidity and instability. It’s a neurodegenerative disorder and research shows that it affects about one per cent of the population from the age of seventy (Savitt, Dawson & Ted, 2006). The greatest development in the treatment of PD was the development of ways to correct dopamine deficiency which is greatly associated with the disease. Halting disease progression has been the greatest nightmare in science and medicine as the medical therapy used is just used to provide temporary relief and not a long term solution for the disease. The need, to do this research on Parkinson’s disease, was necessitated by the fact it is the second most common neurodegenerative disorder (Barbara & Lang, 2014). There are various factors associated with the onset of the disease with various genetic and environmental factors being thought to have an interaction that results to the disease (Bekris, Mata & Zabetian, 2010). Familial Parkinsonism which is detected when patients show symptoms such as rigidity, tremor and slowness in movement has been shown to be caused by mutation in six genes which include SNCA, ATP13A2, PINK1, DJ1, PRKN and LRRK2 (Bekris, Mata & Zabetian, 2010). Other factors, which have been seen as predisposing factors or leading to the disease, include variation in the MAPT, SNCA, and LRRK2. Putting the individual at a vulnerable position makes them to show the symptoms